Natural and Powerful PDE-5 Inhibitors

What are natural and powerful PDE-5 inhibitors or phosphodiesterase type 5 inhibitors (aka. the correct medical term)?

This medical term designs medicine used to inhibit the secretion of the enzyme PDE-5. By doing so, we can prevent the interruption of certain bodily mechanisms that relax blood vessels. Therefore, this type of medicine or in some cases, natural components can lead to powerful erections… because the penis is filled with more blood during the fatidic moment.

PDE-5 inhibitors can restore normal erectile function up to a whooping 70% (for patients suffering from Erectile Dysfunction – ED). Moreover, those inhibitors can treat various cases of ED regardless of their origin.

However, before grabbing a pill, you should know that you can find natural and powerful PDE-5 inhibitors!

Natural and Powerful PDE-5 Inhibitors – How Does it Work?

Among the most known PDE-5 inhibitors, you will find Viagra, Levitra or Cialis containing the chemicals sildenafil, vardenafil or tadalafil. As a matter of fact, most of us are familiar with the results of these so-called miraculous pills. However, these little “miracles” come with a long list of side-effects that would deter most of us from using them long-term.

Instead, let’s understand how they work…and then, you’ll get some natty (natural) alternatives!

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How Does a PDE-5 Inhibitor Work?

During sexual stimulation, the arteries of the penis become larger. Thus, the blood flow towards your third leg increases. Simultaneously, your penis swells and compresses the veins that usually transport your blood far away from your verge. In this way, the length and girth of your phallus is going to increase until a full-on erection.

In the case of an erectile dysfunction, the blood flow necessary for a good erection doesn’t happen because of X factor. For instance, it could be the result of a lack of blood flow towards the penis or a general reduction of blood flow. Thereupon, an erection can’t properly happen. The factors causing the issue can vary: a trouble linked to the blood vessels (cardiovascular disease, atherosclerosis, etc.), a problem located around the nerves of the penis or an inflammation of it.

Physiologically, this translates to a lack of communication between the chemical messenger and the naturally occurring enzymes in the organism. Or, in other words, cGMP (cyclic guanosine monophosphate) and the enzyme PDE-5. The messenger cGMP is activated in the brain during sexual stimulation and favours the relaxation of smooth muscle in the penis. In this way, blood flow and the girth of the penis increases. However, the PDE-5 enzyme decomposes the messenger cGMP.

Let’s Make it Simple:

If your body produces too much PDE-5 enzyme, the messenger cGMP will degrade itself before the beginning of an erection or shortly after.

Thus, PDE-5 inhibitors will inhibit the PDE-5 enzyme in the blood. Consequently, the messenger cGMP won’t decompose earlier than needed. The inhibiting effect will relax blood vessels, thus, improving blood flow and erections!

So, where do we find those natural and powerful PDE-5 inhibitors?

Natural and Powerful PDE-5 Inhibitors – Top 3 Supplements

Instead of chemical molecules that can inhibit the PDE-5 enzyme with an extensive list of side-effects, try the following natural alternatives. The supplements below are natural and when the dosage is respected, devoid of side-effects. Here we go!

Did you know that Turmeric can help with ED and low libido? Click here to know more!

Icariin Extract

Icariin extract is the active ingredient of Horny Goat Weed (or Epimedium). Epimedium has been used for millenaries in Traditional Chinese Medicine to treat erectile dysfunction. Nowadays, researchers are actively looking into this natural product.

Studies have shown that icariin is a natural PDE-5 inhibitor that can also increase testosterone levels. Moreover, icariin regulates the production of cortisol (stress hormone). High levels of cortisol can disrupt testosterone synthesis. (1)

Dosage: Consume 250 to 1000 mg of icariin daily.


Pycnogenol is obtained from the bark of maritime pine. It is found around the Mediterranean region and in the south-west of France. In addition, this is one of the best supplements to improve erectile function.

It’s properties are the result of its capacity to increase nitric oxide production in the body. A gas that improves blood flow and consequently, erections.

A study demonstrated that pycnogenol offers better results than a conventional treatment used to treat chronic venous insufficiency (a cause of ED). (2)

Dosage: Consume approximately 50 mg of pycnogenol 1 to 3 times a day.


Forskolin extract comes from a plant called Coleus Forskohlii. Its utilisation can be traced back to Ayurvedic medicine in India, millenaries ago.

Forskolin has beneficial effects on glaucoma, muscular growth and weight loss. However, the list doesn’t stop there, forskolin can also increase testosterone and of course, inhibit the PDE-5 enzyme.

Researchers have demonstrated that the consumption of forskolin can increase free testosterone levels up to 34% with a daily 50 mg dose!

Dosage: However, the optimal dosage is 500 mg daily. For best results, choose a supplement that has a minimum of 10% of forskolin.

Discover some truly effective aphrodisiacs now!

(1) Potent inhibition of human phosphodiesterase-5 by icariin derivatives. Dell’Agli M, Galli GV, Dal Cero E, Belluti F, Matera R, Zironi E, Pagliuca G, Bosisio E. J Nat Prod. 2008.
(2) Improvements of Venous Tone with Pycnogenol in Chronic Venous Insufficiency: An Ex Vivo Study on Venous Segments. Gianni Belcaro, Mark Dugall, Roberta Luzzi, M. Hosoi, Marcello Corsi. Int J Angiol. 2014.

Vincent Lee